Jill Stein's jump shot with 4:14 to go gave the Falcons a lead they held until the final minute of play, when Brittany Rayburn hit a layup with 51 second left to put Purdue ahead. After a pair of Chrissy Steffen free throws put the Falcons ahead again, Courtney Moses hit a layup with 13.5 seconds remaining to put Purdue ahead for good.
Danielle Havel attempted a three-point shot with second remaining, but the shot was just off the mark and the rebound was swatted out to mid-court.
Alexis Rogers paced the Falcons with 10 points and eight rebounds in the loss, while Steffen added nine points, two assists and two steals, playing in all 40 minutes.
The Falcons went with a three guard system for much of the game, running out a starting lineup of Rogers and Havel at forward and Steffen, Jillian Halfhill and Jessica Slagle at guard.
The Falcons will be back in action Sunday at 12 p.m. as they take on Evansville at the Stroh Center.